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| Id: | 18919
| | Author: | Faria, J. Lopes de. | | Title: | Estudo da reação à lepromina (Mitsuda) em cães: histopatologia, significação / Lerpomin reaction in dogs: histopathology, signification
| | Source: | Rev. bras. Leprol;15(3):195-201, set. 1947. .
| | Abstract: | In this paper, the author first revised what is known about lepromin (Mitsuda) reaction in man. From his review he believes worth-mentioning: the delay in the reaction (nodule); in Mitsuda's antigen bacilli ere indispensable for the development of the nodular phase; the production of late reaction with the waxez of Hansen's bacilli and alcohol-soluble and cloroform-soluble leproma fractions; normal persons without any previous contact with lepers (from non-endemic leprosy regions), presente the nodular reaction; its negativity in children. Next he points out the unsuccessful attempts to trasmit human leprosy to animals. Then he studies the hsitopatology of the hyperergic inflammation, emphasizing the fibrinoid degeneration of the connective tissue, because of Bngeler and Fernandez's paper. He analyses the causative pathogenesis of the tubercle and tuberculoid structures, the mechanism of the necrosis found in inflammatory granulomas and also why the tubercle is invaded by such a great number of neutrophil leukocytes. In the other part of the paper, the author reports his experiments, He made careful macroscopic and microscopic studies of lepromim reaction in ten adult dogs from non leprous communities. He used, as control substances, a normal skin extract (prepared by the same technic of lepromin) and saline. He examined the reactions which take palce within: 5 minutes; 1, 24 and 48 hours; 4, 8, 15, 21, 30, 60 and 90 days. The initial dermic paule (injection paule) to lepromin increased a little (2,2 mm) within the first five minutes and kept growing (1,5 mm more) until the firts hour in half of the animals; then it decreased more and more and disappeared. There was either complete disappearance in 24 or 48 hous, or it was still present as a clear cut erithematous papule, smaller than 10 mm in diameter (except for only one case with 10,5 mm). After the disappearing of the injection papule, the inoculated place was without any macroscopic sign (latency period...(AU)^ien.
| | Descriptors: | HANSENIASE
ANTIGENO DE MITSUDA/ef adv
ANTIGENO DE MITSUDA/anal
ANTIGENO DE MITSUDA/metab
| | Electronic Medium: | http://hansen.bvs.ilsl.br/textoc/revistas/1947/PDF/v15n3/v15n3a04.pdf / pt
| | Location: | BR191.1 |
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